TRPA1 channel mediates organophosphate-induced delayed neuropathy

Organophosphate induced delayed neuropathy.

A 19 year young male who consumed organophosphorous compound and required assisted mechanical ventilation for two weeks, later on developed delayed neuropathy is described.

Organophosphate-Induced Delayed Neuropathy

Organophosphate-induced delayed neuropathy: case report.

Organophosphate induced delayed neuropathy (OPIDN) is an uncommon clinical condition. It occurs in association with the ingestion of great amounts of organophosphate after the stimulation of cholinergic receptor. The clinical picture is characterized by a distal paresis in lower limbs associated with sensitive symptoms. Electrodiagnostic studies show a motor axonal neuropathy. Involvement of th...

Organophosphate induced Delayed

Organophosphorus compounds are common insecticidal agents used in India. Their use as a suicidal agent is also well known often leading to massive organophosphorus-compound intoxication. Although uncommon, delayed neurotoxicity has been consistently reported in literature probably related to the inhibition of neurotoxic esterase. This mechanism is implicated not only in damaging peripheral nerv...

TRPA1 mediates formalin-induced pain.

The formalin model is widely used for evaluating the effects of analgesic compounds in laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; the first phase is thought to result from direct activation of primary afferent sensory neurons, whereas the second phase has been proposed to reflect the combined effects of afferent input and central sensitization ...